P88 | Clinical relevance of vitamin B12 in hospitalized cancer patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Vitamin B12 impairment is common in cancer patients due to several clinical and therapeutic causes, but data regarding their prevalence and significance in this setting are lacking.Methods: We retrospectively enrolled patients hospitalized at our Medical Oncology ward (2017-2022). Plasma B12 levels in pg/ml were stratified as Very Low(VL<200), Low(L200-300), Normal(N300-813) or High(H>813). We collected demographic and clinical data and fitted univariate and multivariate analyses for factors affecting B12 levels.Results: We enrolled 788 patients, B12 level were VL in 14.09% cases, L in 19.42%, N in 49.37% and H in 17.13%. At univariate analysis, females had higher B12 levels compared to males, a negative correlation between B12 and age, folates, albumin, prealbumin total protein was observed and, conversely, vitamin B12 correlated positively with folates(p<0.0001). B12 distribution directly correlated to ECOG-PS levels(p<0.0001) and was higher in advanced compared to early-stage patients, as well as in those who had liver failure. The highest median value was found in breast cancer patients while the lowest in colorectal and gastric cancer. Multivariate analysis confirms the increased probability of H vs. VL B12 in hypoproteinemia, hypoalbuminemia and ECOG PS≥2. Conclusions: To our knowledge, this is the first study investigating B12 levels in a wide group of cancer patients; our data suggest that increased B12 is associated to an impaired clinical status, while in early stage patients B12 deficiency is of concern and may negatively affect the overall outcomes.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413686960