Work

Engineering prime editors in Salvia miltiorrhiza for precise genome modification

Year: 2025

Type: article

Abstract: An optimized prime editing system in the model medicinal plant Danshen (Salvia miltiorrhiza) was developed, enabling base transversions, complex insertions and base substitutions. Precise editing of key genes generated germplasm with elevated contents of the bioactive abietane diterpene tanshinone, advancing synthetic biology applications in medicinal plants.

Source: Journal of Integrative Plant Biology

DOI: 10.1111/jipb.70006

Authors: Qi Yao, Yi Ye, Muyao Yu, Yifu Tian, Qi Liu, Han Zheng, Luqi Huang

Institutions: Shanghai Jiao Tong University, China Academy of Chinese Medical Sciences, Beijing University of Chinese Medicine

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, China Academy of Chinese Medical Sciences, National Key Research and Development Program of China

Awards: G1148627047, G1888231276, G3329228042, G5712294603, G6792141753, G7622638893, G8076008932, G8385610713

OpenAlex ID: W4413698907

FWCI: 1.298

Cites: 10

Cited by: 5

Related to: 10