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Front Cover: Ring‐Rearrangement Driven Formal (3 + 2) Cycloaddition of Enaminone‐Based Thioalkynes with Nitriles to Form Thiazole Containing Bis‐Heterocycles (Eur. J. Org. Chem. 31/2025)

Year: 2025

Type: paratext

Abstract: The Front Cover depicts a synthetic route for pharmaceutically important bis-heterocyclic 3,4-dihydropyridin-2(H)-one containing thiazole derivatives by triflic acid-mediated ring rearrangement and formal (3 + 2) cycloaddition reaction of enaminone-based thioalkynes with nitriles. The outcome of reaction is decided by the substitution pattern on the cyclohexenyl ring. The developed protocol is operationally simple with a shorter reaction time and features a wider substrate scope delivering a very good to excellent yield of products. More information can be found in the Research Article by K. N. Tiwari and co-workers (DOI: 10.1002/ejoc.202500287). Cover designed by K.N.T.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70069

Authors: Chandran Rankan, Abha Sharma, Keshri Nath Tiwari

Institutions: Government Medical College, Kerala University of Health Sciences, National Institute of Pharmaceutical Education and Research, Indrashil University

Language: English

Topic: Synthesis of heterocyclic compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4413740413

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