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Xenotransplantation Literature Update: January–June 2025

Year: 2025

Type: article

Abstract: From January to June 2025, the field of xenotransplantation progressed rapidly toward clinical translation, with landmark compassionate-use cases, peer-reviewed reports of porcine kidney, heart, and liver transplants in humans, and the release of authoritative international guidelines. This literature update summarizes key developments across clinical trials, immunological insights, donor engineering, preservation strategies, infection control, and ethical frameworks, highlighting a growing consensus on the scientific and regulatory roadmap for safe, effective, and equitable xenotransplantation.

Source: Xenotransplantation

DOI: 10.1111/xen.70072

Authors: Kasra Shirini, Joseph M. Ladowski, Raphael P. H. Meier

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Duke University, Duke Medical Center, University of Maryland, Baltimore

Language: English

Topic: Xenotransplantation and immune response

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,550