P20 | Always keep in Mucor-mind fungal infections!
Year: 2025
Type: article
Study design: Case Report
Abstract: Introduction: Mucormycosis is a rare fungal infection caused by ubiquitous fungi belonging to the order Mucorales. It’s most frequently observed in immunocompromised patients or immunocompetent following a significant trauma. We present the case of an immunocompetent woman who developed Mucormycosis after a minor skin trauma.Clinical Decours: A 61-year-old woman, coping with depression and alcohol abuse, was admitted to the hospital due to septic shock caused by a soft tissue infection in her left leg, which developed after a minor skin trauma. Broad-spectrum antibiotic therapy was initiated and subsequently tailored based on specific bacteria identified in soft tissue and blood samples. Due to a worsening wound condition, surgical debridement, along with post-surgical VAC therapy, was performed. Mucor circinelloides was identified through histopathological analysis and cultures of surgical samples. To prevent the risk of a disseminated infection (mortality 70-100%) limb amputation was considered to achieve source control. However, due to the frailty of the patient, we opted for an attempt of conservative approach: bone samples were obtained and tested negative for fungal presence, finally addressing for a potentially avoidable amputation. The patient was successfully treated with surgical curettages, in combination with amphotericin B and isavuconazole.Conclusions: Although rare and more often seen in predisposed patients, Mucormycosis should also be considered in the differential diagnosis of soft tissue infections arising from small skin traumas in immunocompetent patients.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413771870