P03 | Role of GLP-1 RAs on bone metabolism in patients with type 2 diabetes mellitus: longitudinal study
Year: 2025
Type: article
Abstract: Introduction: Diabetic patients are prone to microvascular and macrovascular complications, and bone is also a target organ of diabetes. We wanted to study the effects of GLP-1RAs on bone mineral density and bone metabolism.Materials and Methods: At baseline and after 12 months, the following were performed: carbohydrate metabolism, calcium-phosphate metabolism, bone turnover markers, adiponectin; measurement of bone mineral density using DXA and REMS methods.Results: BMD measured by DXA at the lumbar spine after 12 months of GL1-RA therapy showed a 4.62% reduction in T-score (p<0.05), while a non-statistically significant decrease of 1.7% was observed with REMS (p=n.s). With both methods, DXA and REMS, a statistically significant reduction in T-score was observed at both the femoral neck and total hip levels (p<0.05). A statistically significant increase in CTX levels was observed at 1 year (p<0.05); while we did not observe significant variations in sclerostin levels and bone alkaline phosphatase isoenzyme levels (p=n.s). However, we observed a statistically significant increase in adiponectin levels.Conclusions: This is the first clinical study to investigate the effect of GLP-1 RAs on bone. Based on the data obtained, it is possible to hypothesize that GLP1-RAs are able to act on bone remodeling by reactivating turnover without having negative effects on microarchitecture. Further randomized controlled studies are needed.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413772011