CO21 | The strategy on healthcare-associated infections prevention in patients with previous SARS-CoV 2 infection. Analysis of the cost and consumption of antibiotics
Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose of the study: Healthcare-associated-infections represent frequent complications of hospital care. Active surveillance activities, prevalence and incidence investigations are fundamental, as a described in PNCAR 2022-2025.Materials and Methods: the “Ospedale del Mare” showed a 30% increase in super-infections from MDR germs, particular Acinetobacter B. also in Sars-CoV-2 patients. Within 24 hours of hospitalization, patients underwent rectal swab for MDR germs and nasal swab for MRSA.Results: Comparison between 2021 vs. 2022 showed in 2022 24% increase in positive MRSA nasal swabs in General Medicine (GM), 21% in ICU and 43% in Emergency Medicine (EM). In 2022 there was a 25% increase in positive MDR rectal swabs in GM, 30% in ICU and 41% in EM. Surveillance strategy highlighted an increased rate of MDR germs, particularly Acinetobacter without significant difference in 2022.Conclusions: Early identification of colonized patients in GM led to 3.4% reduction of meropenem DDD (2021 vs. 2022) and -45% of costs, while for ceftazidime/avibactam -55.3% and -52.4%. In EM, 100% DDD reduction, while in ICU there was a +533% DDD increase, with increased cost by 579%. The cost analysis for all UUOOs for ceftazidime\avibactam showed 19% increase, also due to 14% price reduction. The sub-analysis of the ICU data showed that, despite the increased costs for antibiotic therapy and the number of MDR colonization/infections, the mortality rate lowers from 71.8% in 2021 to 63% in 2022 with an average stay in ICU of 17 days in 2021 rather than 16 days in 2022, showing a slight reduction.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413772185