CO23 | Anti-Ro52 associated with Anti-EJ antibodies may predict more severe lung damage in patients with anti-synthetase syndrome
Year: 2025
Type: article
Study design: Case Report
Abstract: Premises: Anti-synthetase syndrome (ASSD) is a rare autoimmune disease characterized by serologic positivity for anti-synthetase antibodies. The lungs emerge as the predominantly impacted organ, typically presenting with manifestations of interstitial lung disease (ILD). The clinical presentation and progression of the disease may vary depending on the specific anti-synthetase antibody present.Description of the Case report: A 45 yrs old patient was admitted with a 2-month history of progressive dyspnea with no other symptoms; ANA test (IFI on Hep2) was positive at a titer of 1:160, and his anti-synthetase antibodies were positive for EJ and Ro52. Other tests (including ENA, anti-DNA, C3, C4 and Echocardiogram) were normal. CT scan showed diffuse interstitial infiltrates in both lungs while the spirometry showed only a slight reduction in the DLCO. The physical examination was unremarkable. Based on clinical presentation and laboratory findings, a diagnosis of ASSD was made and the patient started oral cyclosporine and prednisone with gradual improvement of symptoms. We have scheduled appropriate tight control and follow-up with our multidisciplinary team including a respiratory physicians and an expert ILD radiologist.Conclusions: Different ASSD phenotypes could be related to incidence and severity of ILD and the presence of anti-Ro52 antibodies, in conjunction with Anti-EJ antibodies, could prove valuable not only for their potential to raise diagnostic suspicions but also in their observed association with a higher incidence of ILD and progression of the disease.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413772256