CO35 | Changes in epidemiology of liver cirrhosis patients admitted to an Internal Medicine Unit from 2014 to 2023: a prospective analysis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Metabolic-associated liver disease is increasing worldwide and end-stage liver disease is a frequent cause of admission to Internal Medicine (IM) Units. In this prospective study, we analyse the etiology and outcomes of admissions due to cirrhosis in a secondary hospital in Rome, Italy.Methods: All admissions to IM during 2014-2023 were prospectively recorded along with demographic data, diagnosis, hospital stay and outcome. Patients with cirrhosis were retrospectively analysed for etiology, comorbidities, and clinical outcomes.Results: 6932 admissions to IM from 2014 and 2023 were included; of these, 372 were due to cirrhosis (88% from the Emergency Department, 66.1% males, median age 71 years, IQR 23). Cirrhosis etiology was alcohol 45.4%, viral 44.3%, metabolic 17%, other 6.9%. Concomitant HCC was present in 24.7%; diabetes mellitus was present in 28% of cirrhotics. compared to 17.8% non-cirrhotics (p<0.001). Prevalence of viral etiology fell from 63% in 2014 to 41% in 2023 (p=0.04), while metabolic-associated cirrhosis increased from 6% in 2014 to 28% in 2023 (p=0.07). Mean hospital stay was 10.3±8 days and in-hospital mortality was 9.4% overall. Negative outcomes in cirrhotics (death, transfer to ICU, hospice care) fell from 26% in 2014 to 15.4% in 2023.Conclusions: In the past 10 years, worldwide changes in etiology of chronic liver disease are evident among patients with cirrhosis admitted to IM. Cirrhotic patients have a higher prevalence of diabetes mellitus compared to other IM patients, reflecting the increasing burden of metabolic liver disease.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413772532