CO30 | Risk factor for damage accrual in primary antiphospholipid syndrome: a retrospective single-center cohort study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Premises and Purpose of the study: Despite anticoagulant therapy, in primary antiphospholipid syndrome (PAPS), a higher rate of recurrent events occurs, leading to potentially accrued damage with a negative impact on quality of life. We evaluated risk factors and APS subsets associated with accrual damage.Materials and Methods: We conducted a retrospective single-center study. We assessed medical records of 282 PAPS patients, with a median age of 36 years, followed for a median of 195 months. The primary endpoint was the damage accrual during follow-up, defined as organ impairment present for at least six months or caused permanent loss. The secondary endpoints were early organ damage presented within six months and death.Results: Eighty presented accrual damage at follow-up; 52.5% presented organ damage within the first 6 months after diagnosis; 41.3% had more than one organ damage. The neuropsychiatric domain was the most frequently involved (38.8%), followed by peripheral vasculopathy, renal, and cardiac domains. 7 patients died and damage accrual was associated with a 6-fold risk of death. Microangiopathy and non-criteria manifestations were independent risk factors for accrual damage with 5-fold and 4-fold higher risk, respectively. The cumulative incidence of damage accrual was increased by 5.7-fold and 3.6-fold in patients with microangiopathy and those with non-criteria manifestations.Conclusions: Our data showed a high frequency of damage accrual in APS patients. Microangiopathy and non-criteria manifestations were independent risk factors for damage accrual.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413772553