CO39 | The FADOI-SIMIT Italian register of fever of unknown origins
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background and Aims of the study: Fever of unknown origin (FUO) is a rare syndrome, but it has relevant morbidity, diagnostic complexity and high healthcare costs. From 20% to 50% of FUO cases remain with no diagnosis. Through a national register, a collaboration between the FADOI and SIMIT societies, this prospective study enrolled FUO cases observed in adult or hospitalized patients, or patients evaluated in 28 Italian centers (15 Infective Disease Units, and 13 Internal Medicine Units).Materials and Methods: The fever (≥38.3°C) had to be found in more than one occasion and last >3 weeks, with no diagnosis after the first level exams. The register was active from 2019, October 1, to 2023, June 30. The study included a 6-month follow-up. We excluded HIV-positive, or neutropenic patients, or patients who were hospitalized for other pathologies. One hundred and eighty-seven patients were enrolled: 51% were women, with an average age of 54 (18-96 range); 40% with no comorbidities. Among the 177 patients who were ultimately evaluated, 28% received no diagnosis, 15% a possible diagnosis, and 57% a conclusive diagnosis. Causes include infections (38%), rheumatological (41%), neoplastic (14%), and other causes (7%). PET-CT was made on 65% of patients, leading to diagnosis in 41% of cases. A diagnosis was made after a median 23 days from enrollment; 65% of patients with a conclusive diagnosis had healed by the time of the follow-up.Conclusions: This register gives an up-to-date insight of FUO causes, their evolution, and the diagnostic paths used in Italy.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413772572