Work

Granulomatosis with polyangiitis and microscopic polyangiitis: pathogenesis and clinical manifestations

Year: 2025

Type: article

Abstract: This literature review addresses the epidemiology, genetic markers, pathogenesis, clinical features, and diagnostic approaches of granulomatosis with polyangiitis and microscopic polyangiitis – both antineutrophil cytoplasmic antibody-associated vasculitides. Particular attention is paid to the role of neutrophil activation and the alternative complement pathway in disease development. The review also includes information on avacopan, an orally administered, selective C5a receptor (C5aR1) inhibitor that blocks the C5a complement component signaling pathway.

Source: Modern Rheumatology Journal

DOI: 10.14412/1996-7012-2025-4-86-95

Authors: T. M. Reshetnyak, E. N. Vorkel, K. S. Nurbayeva, A. M. Lila

Institutions: Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Association of Rheumatologists of Russia

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413783689

FWCI: 0.608

Cites: 46

Cited by: 1

Related to: 10