Validation of CCL20-driven CAR-γδ T secreting PD-1 blockade with enhanced trafficking into solid tumor
Year: 2025
Type: article
Abstract: validated using a non-small cell lung cancer (NSCLC) CDX model. The results from CAR-E276 indicated that integrating chemokines, checkpoint blockades, and γδ T cell properties into CAR-T cells facilitated their efficient trafficking into tumor tissues, ensured prolonged persistence, and achieved robust tumor-killing effects without inducing GvHD. Notably, CAR-E276 also exhibited potential for off-the-shelf and allogeneic applications. These findings are expected to offer valuable insights and drive the development of CAR-T therapies targeting solid tumors.
Source: iScience
Authors: Dengji Zhang, Yuan Tang, Wei Sun, Yunkun Guan, Yipeng Cheng, Yuqi Zhu, Xiaying Zhao, Xinyi Yang, Huanzhang Zhu
Institutions: Fudan University, State Key Laboratory of Genetic Engineering
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,240
Award: G6605929022
OpenAlex ID: W4413788056