Work

The Calcium Conundrum: Hypercalcemia of Unknown Etiology

Year: 2025

Type: article

Abstract: Hypercalcemia is a common clinical finding with a wide variety of clinical presentations and etiologies. The differential is broad and includes hyperparathyroidism, malignancy, medication adverse effects, endocrinopathies, and a variety of granulomatous diseases. We present the case of an 84-year-old woman with severe parathyroid hormone-independent hypercalcemia and elevated 1,25-OH Vitamin D. Non-necrotizing granulomas were identified on bone marrow biopsy. After an exhaustive workup for granulomatous disease, the patient was felt to have sarcoidosis isolated to the bone marrow and started on prednisone to suppress 1-alpha hydroxylase activity.

Source: Cureus

DOI: 10.7759/cureus.91200

Authors: Alp Kahveci, Lindsay Moy, Mohamed Eletrebi, Brittany Bettendorf

Institutions: University of Iowa Hospitals and Clinics, University of Iowa Health Care

Language: English

Topic: Sarcoidosis and Beryllium Toxicity Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413791812