P10 | Hypoalbuminemia predicts 6-month all-cause mortality in patients with acute decompensated heart failure
Year: 2025
Type: article
Abstract: Introduction and Background: Hypoalbuminemia is common among elderly patients and it is associated with poor survival in patients hospitalized with acute decompensated heart failure (ADHF). We assessed the impact of hypoalbuminemia among older patients with ADHF admitted to an Internal Medicine division.Materials and Methods: This interim analysis includes 271 out of 498 patients as part of a retrospective cohort study of patients admitted for ADHF during 2022 to the Internal Medicine Division of Ospedale di Circolo and Fondazione Macchi, ASST Sette Laghi, Varese, Italy. Patients were included according to the discharge ICD-9-CM codes of ADHF. The primary endpoint is the prognostic role of hypoalbuminemia (<3.5 g/dL) toward 6-month all-cause mortality.Results: Out of 271 patients, 77.5% of patients had hypoalbuminemia. These ones were older, had more comorbidities (CCI) and frailty (CFS), had higher inflammation (NLR) and NT-proBNP. Across the 6-month follow-up, 30.6% of them died and the survival was much lower in patients with hypoalbuminemia than those with normoalbuminemia (35.7% vs. 13.1, log-rank χ² 11.49, p<0.001; unadjusted HR 3.28, 95% CI 1.58-6.80, p=0.001). Adjusting for potential confounders significant at the univariate analysis (age, obesity, CCI, CFS, NLR, NT-proBNP), hypoalbuminemia independently predicted 6-month all-cause mortality (adjusted HR 2.38, 95% CI 1.01-5.58, p=0.046).Conclusions: Hypoalbuminemia is very frequent among elderly patients admitted to an Internal Medicine division for ADHF and it is independently associated with 6-month all-cause mortality.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413795084