Wnt/β-catenin signaling pathway is essential for the protective effect of Fat soluble Vitamins (A, D, E, and K) on colorectal cancer
Year: 2025
Type: article
Abstract: An essential regulatory pathway involved in many biological processes, such as embryonic development, tissue homeostasis, and cancer progression, is the Wnt/β-catenin signaling pathway. One of the main characteristics of Colorectal Cancer (CRC) is the dysregulation of the Wnt/β-catenin signaling pathway, which plays a significant role in tumor development, invasion, and metastasis. Adenomatous polyposis coli (APC) gene mutations account for 80–90% of sporadic cases of CRC. Typically, APC mutations occur early in the development of CRC. APC normally suppresses tumors by encouraging β-catenin degradation. Fat-soluble vitamins, such as A, D, E, and K, are essential for many physiological functions. They may also interact with signaling pathways like the Wnt/β-catenin pathway. The involvement of the Wnt/β-catenin signaling pathway in the protective effect of Fatsoluble vitamins against CRC is the main topic of this review. Moreover, a comprehensive understanding of the underlying molecular mechanisms of fat-soluble vitamins-mediated Wnt/β-catenin signaling pathway regulation is required to target therapeutic targets for CRC prevention and treatment effectively.
Authors: Hossna M Ismail, Ehab S Shatat, Abdel Aziz S Shatat
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4413795432