CO09 | Homocysteine: marker of neurodegeneration in patients with alcohol dependence syndrome
Year: 2025
Type: article
Abstract: Aims: Alcoholism correlates with increased homocysteine, whose metabolism requires vitamins B12, B6, and B9 as cofactors. Homocysteine overcomes BBB by acting as a neurotoxin, promoting demyelination, leading to up-regulation of NMDA receptors, glutamate accumulation and neuronal lipid peroxidation, cellular changes underlying phenomena such as learning, memory and dysesthesia. The study assesses the association between hyperhomocysteinemia in alcoholics and central/peripheral neuronal damage.Methods: MOCA and MMSE psychometric instruments, EMG. Results: 45 patients underwent homocysteine assays at enrollment found to be above threshold values in 96% of cases; at T0 performed neurocognitive assessment by MOCA and MMTE with mild to moderate impairment of cognitive abilities in 65% of cases. EMG performed at T0 documented mild signs of neurogenic distress in 30% of patients. After a course of parenteral B vitamins and continued vitamin oral supplementation for 6 month repeat tests were performed providing improvement in cognitive abilities in 85% of cases: moderate/light to mild. Repeat EMG at 6 months was also negative in 20% of patients with mild signs of distress. Homocysteine values at T6 were in range in 99% of patient.Conclusions: Hyperhomocysteinemia of alcoholics represents a risk factor for neurodegeneration that is potentially modifiable with pharmacological strategies of vitamin replenishment and total abstention from potus.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413795652