P149 | Acute and long-term management of venous thromboembolism through the post-COVID-19 pandemic era
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background and Aim: COVID-19 increases the risk of venous thromboembolism (VTE) through a complex interplay of mechanisms collectively termed immunothrombosis. Limited data exist on VTE challenges in the acute setting throughout a dynamic long-term follow-up compared to non-COVID-19 patients. This study aimed to investigate acute and long-term management and complications in VTE patients with and without COVID-19.Materials and Methods: Prospective, observational, single-center cohort study on VTE patients followed from acute care until 24 months post-diagnosis.Results: 157 patients, 30 with COVID-19-associated VTE and 127 unrelated to COVID-19, were enrolled. The mean follow-up was 10.8 (±8.9) months. Baseline characteristics were similar, but COVID-19 patients had fewer comorbidities (1.3±1.29 vs. 2.26±1.68, p<0.001) and a lower probability of remaining on anticoagulant therapy after three months (p<0.003). The most used initial therapy was low molecular weight heparin in 130/157 cases, followed by long-term therapy with direct oral anticoagulants in 123/157. Two (6.7%) COVID-19 vs. three (2.4%) non-COVID-19 patients (p=0.243) had major hemorrhagic events. All hemorrhagic events occurred within the first three months. Three non-COVID-19 patients developed chronic thromboembolic pulmonary hypertension. Mortality was 0% in patients with COVID-19 compared to 9.4% in the non-COVID-19 subgroup (p=0.027).Conclusions: Our study underscores the evolving nature of VTE management, emphasizing the importance of personalized risk-based approaches.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413798358