Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement
Year: 2025
Type: preprint
Source: medRxiv
Authors: Jan Homann, Roxanna Korologou-Linden, Vivian Viallon, Sarah Morgan, Valerija Dobricic, Laura Deecke, Julia P. Schessner, Karl Smith-Byrne, Daniel Birtles, Yujia Zhao, Joanne Wuu, Fanny Artaud, Fatema Hajizadah, Jose Maria Huerta, Olena Ohlei, Mikhail Lebedev, P. Martijn Kolijn, Marcela Guevara, Ana Jimenez-Zabala, María José Sánchez, Camino Trobajo-Sanmartín, Sandra M. Colorado-Yohar, Sonia Alonso-Martín, Dafina Petrova, Sabina Sieri, Klaus Berger, Susan Peters, Nick Wareham, Rudolph Kaaks, Ruth C. Travis, Roel C. H. Vermeulen, Ioanna Tzoulaki, Alexis Elbaz, Matthias Mann, Carlotta Sacerdote, Giovanna Masala, Verena Katzke, Michael Benatar, Lars Bertram, Lefkos Middleton, Elio Riboli, Marc J. Gunter, Pietro Ferrari, Oliver Robinson, Christina M. Lill
Institutions: University of Münster, Imperial College London, Centre international de recherche sur le cancer, Queen Mary University of London, Blizard Institute, University of Lübeck, Max Planck Institute of Biochemistry, University of Oxford, Utrecht University, University of Miami, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, Instituto Murciano de Investigación Biosanitaria, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Basque Government, Biogipuzkoa Health Research Institute, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Universidad de Antioquia, Instituto de Salud Carlos III, Biomedical Research Networking Center on Neurodegenerative Diseases, Hospital Universitario Virgen de las Nieves, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Cambridge, MRC Epidemiology Unit, Medical Research Council, German Cancer Research Center, University Medical Center Utrecht, Academy of Athens, Biomedical Research Foundation of the Academy of Athens, University of Copenhagen, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: World Health Organization, Compagnia di San Paolo, Cure Alzheimer's Fund, Rare Diseases Clinical Research Network, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, European Commission, Deutsche Forschungsgemeinschaft, ZonMw, Ministero della Salute, Westfälische Wilhelms-Universität Münster, Associazione Italiana per la Ricerca sul Cancro, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, Rijksinstituut voor Volksgezondheid en Milieu, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences
Awards: Aetiology of type 2 diabetes and related metabolic disorders, G1136667113, G2286363763, G261809072, G2714613917, G3328679326, Metabolomic and omic assessment of biological ageing across the life-course (METAGE), G4409035895, G4844208673, G4881195352, The EPIC-Norfolk prospective population study: biological and behavioural determinants of health and disease in an ageing population, G527520901, G5315906942, G5469230434, G574262416, G6274749655, G6636188017, G6896564351, G6923329853, G7112453972, EPIC-Oxford: benefits and risks of plant-based diets, Metabolomic and omic assessment of biological ageing across the life-course (METAGE), G899966268, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)
OpenAlex ID: W4413800244