Work

3,3'-Linked BINOL macrocycles: optimized synthesis of crown ethers featuring one or two BINOL units

Year: 2025

Type: article

Abstract: Chiral macrocycles hold significant importance in various scientific fields due to their unique structural and chemical properties. By controlling their size, shape, and substituents, chiral macrocycles offer a platform for designing and synthesizing highly efficient catalysts, chemosensors, and functional materials. We have recently made strides in developing macrocyclic organocatalysts; however, their synthesis remains challenging. In this work, we aimed to discover a straightforward method for producing a diverse range of chiral macrocycles, thereby enabling further exploration in the field of interlocked and macrocyclic organocatalysts. We successfully established optimized synthetic routes for the synthesis of chiral macrocycles containing one or two stereogenic units, featuring varying ring sizes and substituents (21 examples in total).

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.21.134

Authors: Somayyeh Kheirjou, Jan Riebe, Maike Thiele, Christoph Wölper, Jochen Niemeyer

Institution: University of Duisburg-Essen

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Alexander von Humboldt-Stiftung, Deutsche Forschungsgemeinschaft

Awards: G1753440237, G331363160, G7361585222