CO01 | Cardiovascular and metabolic effects of GLP-1RAs in patients with type 2 diabetes mellitus: a preliminary longitudinal study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Aim: Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder in the world. T2DM involves numerous cardiovascular complications, which are a cause of morbidity, mortality and increased public spending worldwide. The real challenge of new diabetes drugs is to prevent cardiovascular risk. The new receptor agonists for glucagon-like peptide-1 (GLP-1RAs) have been shown to play a key role in cardiovascular risk too.Methods: We carried out a longitudinal study of 12 months evaluating the cardio-metabolic effects of GLP-1RAs on a cohort of 80 Caucasian patients with T2DM referred to the Department of Internal Medicine at the University Hospital of Siena, Italy.Results: GLP-1RAs led to several positive changes in our study population, in addition to a weight loss we observed: a change in fat distribution with reduction in the percentage of visceral fat (1.21 vs. 1.17, p<0.05); a significant reduction in the levels of LDL cholesterol (p<0.05) and triglycerides.(p<0.01); an increase in the values of adiponectin which could reflect a reduction in insulin resistance and in inflammatory state. We also observed a reduction in microalbuminuria and in media-intimal thickness at the epiaortic vessels (p=0.05).Conclusions: In patients with T2DM 1-year therapy with GLP-1RAs has a positive effect on the main determinants of cardiovascular risk including body weight, visceral fat, dyslipidemia and atherosclerosis. Moreover, the increase in adiponectin may play a pivotal role in controlling the inflammatory state and the mechanisms of vascular damage.
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413800950