CO15 | A single-center experience in screening patients for carbapenem-resistant enterobacteriaceae at admission
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background and Aims: Bloodstream infections due to carbapenem-resistant enterobacteriaceae (CRE) is a leading cause of morbidity and mortality. Our aim was to investigate the prevalence of colonization from CRE among patients admitted to Internal Medicine Unit.Materials and Methods: We retrospectively collected rectal swab specimens from patients at admission between November and December 2023. Laboratory searched for gram negative resistance markers analysing rectal samples with multiplex PCR-based BD MAX assay to detect the 5 major carbapenemase families (OXA-48, VIM/IMP, KPC, NDM).Results: 184 rectal samples were collected. The overall carriage rate of CRE was 6% (KPC and NDM in 73% and 27% patients, respectively). Seventy-two patients with positive rectal swabs showed almost one of the following features: hospitalization/antibiotics in the last month, haemodialysis. In our cohort positivity rate of urine and blood cultures was 5% and 16% respectively. No correlation between CRE colonization and urine positivity was found; 18% patients showed both blood cultures and rectal swab positive and died. Mortality rate in patients with positive blood cultures and negative rectal swab was 33%.Conclusions: the number of positive rectal swabs compared to the total number of hospitalized patients remained low thanks to the procedures adopted after identification of carriers. Colonization increases the risk of infection by multidrug-resistant bacteria, having a remarkable impact on prognosis (as we observed mortality up to 100% in patient with blood culture and rectal swab positive).
Source: Italian Journal of Medicine
Authors: Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu, Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid, Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua, Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar, Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel, Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen, Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico, Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4413800985