Work

Optimizing surgical management for pulmonary artery sarcoma: A 24-year single-center analysis

Year: 2025

Type: article

Abstract: Objective: Pulmonary artery sarcoma (PAS) is a rare and aggressive malignancy often misdiagnosed as chronic thromboembolic pulmonary hypertension. This study aimed to evaluate long-term outcomes after surgical treatment and to compare traditional surgical approaches with an integrated strategy developed at a high-volume center. Methods: We retrospectively reviewed 31 patients who underwent surgery for PAS at Fuwai Hospital between January 2000 and March 2024. Patients were categorized into 2 groups on the basis of surgical approach: traditional resection versus an integrated strategy involving imaging-guided planning, en bloc resection, selective pulmonary endarterectomy, and vascular reconstruction. Kaplan-Meier survival analysis was performed among 26 patients who survived the perioperative period. Results: = .0234), with no early postoperative deaths and lower recurrence rates. Conclusions: An integrated surgical approach combining radical resection, pulmonary endarterectomy, and vascular reconstruction may confer a survival advantage in selected patients with PAS. Early diagnosis and tailored surgical planning are critical to optimizing long-term outcomes in this rare and lethal disease.

Source: JTCVS Open

DOI: 10.1016/j.xjon.2025.08.006

Authors: Hang Xu, Xinhe Xu, Wu Song, Jiade Zhu, Zhaoji Zhong, Sheng Liu