Work

Persistent Renal Activity Despite Systemic Remission After Hematopoietic Stem Cell Transplantation in Lupus Nephritis

Year: 2025

Type: article

Abstract: Systemic lupus erythematosus (SLE) remains one of the most prevalent autoimmune diseases. Despite the advances in immunosuppressive therapies, a considerable proportion of patients continue to be refractory to conventional treatments. In this context, autologous hematopoietic stem cell transplantation (HSCT) has emerged as a promising strategy aimed at resetting the immune system and inducing long-term remission [1–4]. The potential role of HSCT in SLE was first demonstrated by Marmont in 1998 [5], and subsequent studies have further supported its efficacy and safety, reporting 5-year disease-free survival rates between 70% and 85% [6,7].

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2025.08.025

Authors: Irene Martin Capon, María Galindo, María Calbacho, J.M. Sánchez-Pina, Enrique Morales

Institutions: Hospital Universitario 12 De Octubre, Universidad Complutense de Madrid, Research Institute Hospital 12 de Octubre

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800