Go-Real: Real-World Evaluation of Antioxidant Properties of Grapefruit and Rosemary Combination Against Light-Induced Damage in Indian Population
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Oral sun protection agents have gained increasing attention as adjuncts to topical sunscreens, particularly in climates with high Ultraviolet (UV) exposure. A combination of Mediterranean rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) extract has demonstrated antioxidant and anti-inflammatory properties with potential photoprotective benefits. However, real-world clinical data on its use in Indian populations is limited. Objective: This study aimed to evaluate the real-world use, safety and perceived benefits of a formulation containing Mediterranean rosemary and grapefruit extract (Golite-OSP) as an oral photoprotective agent in Indian dermatological practice. Methods: A retrospective analysis was conducted across 85 dermatology centres in India, including 850 adult patients who were prescribed the formulation. Data collected included demographic characteristics, dermatological diagnoses, dosage patterns, treatment duration, adverse events and both physician and patient assessments of efficacy and tolerability. Results: The mean age of participants was 32.2 years; 59.2% were female. The most common indications were acne (51.1%), rosacea (30.8%) and eczema (10.9%). The majority (92.4%) received once-daily dosing, with an average treatment duration of 9.6 weeks. Both physicians and patients reported favourable efficacy and tolerability in over 93% of cases. Adverse events were rare (0.4%), limited to mild gastrointestinal symptoms. Over 75% of patients reported improvements in skin attributes such as lightness, moisturisation, firmness and tone uniformity. Conclusion: The combination of Mediterranean rosemary and grapefruit extract appears to be a safe and well-tolerated oral photoprotective agent with high levels of patient satisfaction and potential cosmetic benefits. Further controlled studies are warranted to confirm these findings.
Source: Journal of Dermatology Research
Authors: Rajashree Dhar, Jyotsna Deo, Vikas Sharma, Rashmi Gaurav Mahajan, Priya Ramanathan, Uday Kulkarni, Dinesh Hawelia, Atul Bothra, Nishita Ranka, Varun Tyagi
Institution: USV (India)
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413802629