State of the art biology, progression, and clinical management of monoclonal B-cell lymphocytosis (MBL): consensus report from the Intercepting Blood Cancers Workshop Committee
Year: 2025
Type: article
Abstract: In March 2023 and 2024, a panel of international experts convened at the first and second Intercepting Blood Cancers (IBC) Workshops, with the aim of better appreciating the diagnostic challenges, pathophysiology, and potential therapeutic interventions for precursor malignant hematology conditions. Here, we report a summary of the proceedings from the sessions focused on monoclonal B-cell lymphocytosis (MBL)/chronic lymphocytic leukemia (CLL). We highlight four main content areas: biology of MBL, clinical implications of MBL, progression of MBL and transformation from indolent CLL to aggressive disease, and opportunities for therapeutic intervention in early CLL. We additionally outline key consensus management recommendations and research goals.
Source: Blood Cancer Journal
Authors: Christine E. Ryan, Inhye E. Ahn, Aswin Sekar, Andrew Rawstron, Julia Almeida, Iñaki Martin-Subero, Erin M. Parry, Miguel Alcoceba, Dinis P. Calado, Alberto Orfao, Anton W. Langerak, Hendrik Veelken, Petra Langerbeins, Deborah M. Stephens, Sameer A. Parikh, Carsten U. Niemann, Sandrine Roulland, Kostas Stamatopoulos, Susan L. Slager, Tait Shanafelt, Paolo Ghia, Jessica Okosun, Matthew S. Davids
Institutions: Dana-Farber Cancer Institute, Leeds Teaching Hospitals NHS Trust, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, Instituto de Salud Carlos III, Instituto de Investigación Biomédica de Salamanca, Centro de Investigación del Cáncer, Centro de Investigación Biomédica en Red de Cáncer, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Complejo Hospitalario de Salamanca, The Francis Crick Institute, Erasmus MC, Leiden University Medical Center, University of Cologne, University Hospital Cologne, Deutsche CLL Studiengruppe (DCLLSG), University of North Carolina at Chapel Hill, Mayo Clinic, Copenhagen University Hospital, Rigshospitalet, Centre National de la Recherche Scientifique, Inserm, Aix-Marseille Université, Centre d’Immunologie de Marseille-Luminy, Centre for Research and Technology Hellas, Stanford Medicine, Stanford University, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Queen Mary University of London, Barts Cancer Institute, Dana-Farber/Harvard Cancer Center
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,290
Awards: G6349138484, G719245541, G9000045441
OpenAlex ID: W4413806397