Work

Efficacy and Toxicity of Inotuzumab Ozogamicin for Treatment of Relapsed/Refractory B‐Cell Acute Lymphoblastic Leukemia in Pediatric and Young Adult Patients After CD19‐Chimeric Antigen Receptor T‐Cell Therapy

Year: 2025

Type: article

Abstract: We retrospectively analyzed outcomes for nine children and young adults who were treated with inotuzumab ozogamicin (InO) for relapsed/refractory (R/R) B-acute lymphoblastic leukemia (ALL) after CD19-chimeric antigen receptor T-cell therapy (CART). After InO cycle 1, overall response rate was 77.8%; 66.7% achieved measurable residual disease (MRD)-negative remission. One-year event-free survival (EFS) was 37.5%; 1-year overall survival (OS) was 50%; 2-year EFS was 37.5%; 2-year OS was 37.5%. Median survivor follow-up is 2.9 years (0.5-4.7). Significant adverse events included prolonged cytopenias, hepatotoxicity, and post-transplant sinusoidal obstructive sydrome. InO showed promising efficacy as treatment for children and young adults with R/R B-ALL after CD19-CART. Extramedullary disease prior to InO and positive MRD after InO cycle 1 were associated with poor outcomes.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.32013

Authors: Paula Ogrodnik, Eric Anderson, Nicholas Gloude, Deborah Schiff

Institutions: University of California San Diego, Rady Children's Hospital-San Diego

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,640