Predictive Factors for HBsAg Seroconversion Following Acute Hepatitis B Virus Infection: A Multicenter BUHASDER Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Experience with the effect of antiviral therapy on HBsAg seroconversion in acute hepatitis B is limited. We aimed to evaluate the factors affecting HBsAg seroconversion in patients with acute hepatitis B (AHB) receiving antiviral treatment. We performed a retrospective and multicenter study involving 107 adult patients who received antiviral treatment for AHB between January 2018 and December 2024. The median age was 48 (min–max, 18–91) years, and 66.3% of the patients were male; 70 patients with 24-week follow-up (15 patients without HBsAg seroconversion versus 55 patients with HBsAg seroconversion) were compared based on HBsAg seroconversion status. Multivariate logistic regression analysis revealed that age was independently associated with HBsAg seroconversion (odds ratio = 0.926; 95% confidence interval (CI) 0.874 to 0.981; p = 0.009). A one-year increase in age was associated with a 0.926-fold decrease in HBsAg seroconversion. In conclusion, age was an independent predictor of HBsAg seroconversion following acute hepatitis B virus infection.
Source: Viruses
DOI: 10.3390/v17091182
Authors: Ozge Caydasi, Derya Öztürk Engin, Ömer Karaşahin, Ayşe Batırel, Süleyman Dolu, Müge Toygar Deniz, Sıla Akhan, Kemalettin Özden, Selma Tosun, Burak Sarıkaya, Levent Görenek, Merve Çelik Aydoğdu, Eyüp Arslan, Fatma Yılmaz Karadağ, Serpil Erol, Semiha Çelik Ekinci, Ahmet Şahin, Müge Özgüler, Pınar Yürük Atasoy, Derya Seyman, Süleyman Yıldırım, Gözde Derviş Hakim, Tuba Damar Çakırca, Özlem Bayraktar Saral, Tuğba Sarı, Türkkan Öztürk Kaygusuz, Süleyman Günay, Şükran Köse
Institutions: Sağlık Bilimleri Üniversitesi, Erzurum Regional Training and Research Hospital, Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Dokuz Eylül University, Kocaeli Üniversitesi, Atatürk University, İzmir Şehir Hastanesi, Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Fatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi, Gaziantep İslam Bilim ve Teknoloji Üniversitesi, Ankara Bilkent City Hospital, Antalya Eğitim ve Araştırma Hastanesi, Şanlıurfa Mehmet Akif İnan Eğitim ve Araştırma Hastanesi, Pamukkale University, Fırat University, Izmir Kâtip Çelebi University
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,137
OpenAlex ID: W4413811345