Synthesis of some new pyrimidine-based pyrene/benzochromene hybrids as EGFR kinase inhibitors in HCT-116 cancer cells through apoptosis
Year: 2025
Type: article
Abstract: = 72.3 nM). Compound 4b treatment induced apoptosis in HCT-116 cancer cells by 30.2-fold, arresting the cell cycle at the G1-phase. It upregulated the apoptosis-related genes using the RT-PCR. Finally, a molecular docking study highlighted the binding interactions with key amino acids inside the EGFR binding site.
Source: RSC Advances
Authors: Yassin Adam A. Mohammed, Nabila A. Kheder, Mohamed S. Nafie, Ashraf A. Abbas, Kamal M. Dawood
Institutions: Cairo University, Suez Canal University, University of Sharjah
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
OpenAlex ID: W4413814276