Year: 2025
Type: article
Study design: Systematic Review
Abstract: The aim of this study is to analyze what the literature presents regarding the use of probiotics and paraprobiotics as complementary therapies in the treatment of atopic dermatitis (AD) in children and adolescents. A systematic review was carried out of articles indexed in the PubMed, Lilacs, Scielo and Embase databases, which included interventions with probiotics and paraprobiotics. The selection followed the PRISMA strategy, focusing on randomized clinical trials published between 2014 and 2024. Fifty-seven articles were identified, of which 14 met the inclusion criteria. The studies analyzed the SCORAD index (Severity Scoring of Atopic Dermatitis) and indicated a significant reduction in AD symptoms in 53.8% of the clinical trials that used probiotics, with emphasis on the strains Lacticaseibacillus rhamnosus GG, Bifidobacterium bifidum, Lactobacillus sakei proBio65, among others. The results have also shown an improvement in patients' quality of life in some studies and a reduction in the use of medication in others, although the evidence varies depending on the type of probiotic and the context of the treatment. The use of probiotics has potential as a therapeutic adjuvant for AD, but the methodological variability between studies limits definitive conclusions.
Authors: Thalyta Sales Emery, Aryanne Da Silva Nascimento, Larissa De Oliveira Soares, Selly Martins Soares, Tacy Santana Machado, Myrtis Katille De Assunção Bezerra
Institution: Universidade Federal de Alagoas
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4413814930