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Extracellular vesicles from post-COVID-19 patients alter endothelial function under protein restriction

Year: 2025

Type: article

Abstract: Our study demonstrated that circulating extracellular vesicles (EVs) from patients 1 and 6 mo after severe COVID-19 altered endothelial function under protein restriction but not in healthy vessels. Post-COVID EVs enhanced the contribution of H 2 O 2 to endothelium-dependent relaxation, associated with reduced catalase and increased 4-HNE-modified protein expression. These findings identified EVs from long COVID patients as potential mediators of endothelial dysfunction particularly under malnutrition-related conditions.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00450.2025

Authors: Geiza Rafaela Bobato, Juliana Quinholi Rocha, Daniele Mendes Guizoni, Natalia Ribeiro Cabacinha Nóbrega, Ludmilla David de Moura, Matheus Lavorenti Rocha, Licio Augusto Velloso, Everardo Magalhães Carneiro, Ligia de Moraes Antunes-Correa, Ana Paula Davel

Institutions: Universidade Estadual de Campinas (UNICAMP), Universidade Federal de Goiás

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4413815628

FWCI: 0.783

Cites: 42

Cited by: 3

Related to: 10