Work

Impaired visually guided behavior in a mouse model of Parkinson’s disease

Year: 2025

Type: article

Abstract: Sensory deficits are commonly observed in patients with neurodegenerative diseases. Declined vision is frequently reported in Parkinson's disease (PD). However, visual impairments in animal models of PD are poorly understood. We observed visual discrimination deficits in parkinsonian mice that were improved by low concentrations of chronically injected l-DOPA. Future clinical research could help to elucidate the effect of pharmacological treatments in the amelioration of visual deficits of patients with PD.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00307.2025

Authors: Gamaliel Mendoza-Cuevas, Job Perez-Becerra, Ricardo Velazquez-Contreras, Vladimir Calderon, Luis Carrillo-Reid

Institution: Universidad Nacional Autónoma de México

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Kavli Foundation, Consejo Nacional de Ciencia y Tecnología, Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México