Work

Interventional management of chest wall sarcomatoid carcinoma mimicking breast cancer metastasis: A case report

Year: 2025

Type: article

Abstract: RATIONALE: Breast cancer patients have an increased risk of developing second primary malignancies, with lung cancer accounting for approximately 5% of cases. Differentiating between metastatic disease and a second primary malignancy remains a diagnostic challenge. PATIENT CONCERNS: A 45-year-old woman with a history of triple-negative breast cancer presented with a newly detected chest wall nodule during routine follow-up. DIAGNOSES: Contrast-enhanced imaging suggested metastatic disease. However, biopsy and immunohistochemistry confirmed a second primary lesion, consistent with either pulmonary sarcomatoid carcinoma or chest wall sarcoma. INTERVENTIONS: The patient underwent a multimodal interventional regimen, including transarterial embolization followed immediately by radiofrequency ablation. OUTCOMES: At 1 month post-treatment, follow-up imaging demonstrated significant tumor shrinkage with no evidence of local recurrence. LESSONS: This case underscores the importance of comprehensive diagnostic evaluation to distinguish metastatic disease from second primary malignancies in breast cancer patients. It also highlights the potential of interventional therapy as a minimally invasive treatment option for inoperable tumors, with multidisciplinary management being essential to optimize outcomes and prognosis.

Source: Medicine

DOI: 10.1097/md.0000000000044090

Authors: Qiyu Zhang, Qiongyu Liang, Jiapeng Sun, Chi Xu

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950