Work

The circITSN1/eIF4A3/Itsn1 axis, a potential new molecular entry point for managing postoperative cognitive dysfunction

Year: 2025

Type: article

Abstract: Postoperative cognitive dysfunction (POCD) is the impairment of cognitive abilities in elderly patients after surgery. Among others, it encompasses neurophysiological changes and therefore impairment in the ability to learn, think, and memorize.1 While there are some patients with a risk of developing a form POCD that persists for more than a year, most cases show a reversible phenotype, with cognitive abilities being restored after several weeks or months.2 As there is no specific treatment, however, to speed up the healing process, prevention strategies are of great importance.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2025.102674

Authors: Sedef Ersoy, Christian Bär

Institutions: Medizinische Hochschule Hannover, Fraunhofer Institute for Toxicology and Experimental Medicine

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900