Work

The Wnt–NAD+ axis in cancer, aging, and tissue regeneration

Year: 2025

Type: review

Abstract: The intricate interplay between Wnt signaling and nicotinamide adenine dinucleotide (NAD +) biosynthesis has emerged as a crucial axis that influences aging and tissue regeneration. Wnt signaling, a key regulator of cellular proliferation, differentiation, and tissue homeostasis, intersects with NAD + metabolism, a cornerstone of cellular energy balance and genomic stability. This relationship is mediated through shared regulatory pathways involving sirtuins, poly(ADP-ribose) polymerases (PARPs), and metabolic enzymes which are sensitive to cellular NAD + levels. Dysregulation of either pathway is implicated in cancer, age-related decline, and impaired regenerative capacity. This review consolidates current knowledge of the Wnt–NAD + axis and highlights its cooperative roles in maintaining tissue integrity and combating the effects of aging. Furthermore, it explores therapeutic approaches targeting this axis to restore tissue health and enhance the capacity for repair, thereby offering promising avenues for addressing age-associated pathologies.

Source: Trends in Cell Biology

DOI: 10.1016/j.tcb.2025.07.006

Authors: Jilian Lamprecht, Sundos Abu Sanad, Anjali P. Kusumbe, Shukry J. Habib

Institutions: University of Lausanne, Nanyang Technological University, Multidisciplinary Institute of Ageing

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030