Year: 2025
Type: article
Abstract: Currently, flexible sensors based on electrochemical principles are predominantly limited to single-parameter detection, making it challenging to meet the demand for synchronous monitoring of multiple analytes in complex physiological environments. This study presents a 3D-printed flexible sensor for synchronous glucose/pH detection. Glucose was quantified via H2O2 oxidation current (GOD-catalyzed reaction), while pH was measured through polyaniline (PANI) resistance changes. The ionogel-based microneedle electrode ensures mechanical robustness. At 0.2 V, optimal signal decoupling was achieved: glucose oxidation current dominates, while PANI’s polarization effect is minimized. Neutral pH minimally affected glucose oxidase (GOD) activity, and low glucose concentrations induced negligible pH interference, ensuring orthogonality. In artificial interstitial fluid, the sensor showed glucose: linear response (0.5–2.5 g·L−1, 0.288 μA·mM−1·cm−2); pH: piecewise-linear sensitivity (0.155 Ω/pH·cm2 for pH > 7; 0.135 Ω/pH·cm2 for pH < 7). The design enables real-time multiparameter monitoring with high selectivity, addressing current limitations in flexible electrochemical sensors.
Source: Sensors
DOI: 10.3390/s25175358
Authors: Shao Lin, Yu Li, Zhenyao Yang, Qiuzheng Li, Bohua Pang, Yin Feng, Jianglin Fu, Guangmeng Ma, Yu Long
Institution: Guangxi University
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,137
Award: G7008009571
OpenAlex ID: W4413824753