Lipidome profile of cystic fibrosis-related diabetes, type 1 and type 2 diabetes mellitus: potential links to inflammation and glucose and lipid metabolism
Year: 2025
Type: article
Abstract: CFRD is characterized by altered lipid metabolism, insulin deficiency, and insulin resistance, which are distinctive features that partially overlap with both T1DM and T2DM. Systemic inflammation with elevated free FA and reduced plasma lipids is also present in CFRD. Lipids are increased in lung biopsies, whose lipidomic profiles are similar to those of blood-derived EVs. CFRD develops ectopic lipid accumulation in the lungs, correlating with heightened local inflammation and reduced plasma lipid transport.
Authors: Alessandra Mingione, Cristian Loretelli, Michele Dei Cas, Francesca Pivari, Matteo Barcella, Ivan Merelli, Aida Zulueta, Rita Paroni, Letizia Morlacchi, Valentina Vaira, Francesca Gillani, Marco Piccoli, Luigi Anastasia, Elisabetta Albi, Ilaria Righi, Mario Nosotti, Paolo Fiorina, Anna Caretti, Lorenzo Rosso, Franco Folli, Paola Signorelli
Institutions: University of Milan, Institute of Biomedical Technologies, National Research Council, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Vita-Salute San Raffaele University, IRCCS Policlinico San Donato, University of Perugia, ASST Fatebenefratelli Sacco, Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G5969171499
OpenAlex ID: W4413825233