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PD-1-Ab therapeutic hypothyroidism associated with decreased of peripheral blood CD4 + T cells and addressed prophylactic medication of thyroxine administration

Year: 2025
Type: article
Abstract: This study explored the immunopathogenic mechanism of immune checkpoint inhibitor associated hypothyroidism through T-cell phenotype and spatial transcriptome sequencing of thyroid glands of mimicked mice model. The findings revealed decreased CD4 + T-cell subset and subsequently featured by upregulated IL-17 signaling pathway. The prophylactic thyroxine was recommended in the early onset of hypothyroidism.
DOI: 10.1152/ajpendo.00192.2025
Authors: Linyao Lu, Congcong Li, Wei Wei, Guanghui Ma, Xinna Zhou, Xiaoli Wang, Shuang Wang, Jun Ren
Institutions: Chinese Academy of Sciences, Fudan University, Pudong Medical Center, Institute of Process Engineering, University of Chinese Academy of Sciences, Capital Medical University, Beijing Shijitan Hospital, Shanghai Medical College of Fudan University, Duke Medical Center
Language: English
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W4413825319
FWCI:
Cites: 44
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Related to: 10