Work

Mesolimbic dopamine ramps reflect environmental timescales

Year: 2025

Type: article

Abstract: Mesolimbic dopamine activity occasionally exhibits ramping dynamics, reigniting debate on theories of dopamine signaling. This debate is ongoing partly because the experimental conditions under which dopamine ramps emerge remain poorly understood. Here, we show that during Pavlovian and instrumental conditioning, mesolimbic dopamine ramps are only observed when the inter-trial interval is short relative to the trial period. These results constrain theories of dopamine signaling and identify a critical variable determining the emergence of dopamine ramps.

Source: eLife

DOI: 10.7554/elife.98666.3

Authors: Joseph R Floeder, Huijeong Jeong, Ali Mohebi, Vijay Mohan K Namboodiri

Institutions: University of California, San Francisco, University of Wisconsin–Madison

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500