Evaluating the Implementation Success of an Intensity‐Adapted Guideline for Pediatric Acute Myeloid Leukemia in Malawi: An Observational‐Implementation Study Protocol
Year: 2025
Type: article
Study design: Study Protocol
Abstract: Acute myeloid leukemia (AML) is most often incurable in low-resource settings. To address this challenge, the International Society of Paediatric Oncology (SIOP) developed an intensity-adapted AML practice guideline in 2019. Here, we present the protocol of an observational-implementation study evaluating the SIOP guideline in Malawi. The purpose of this manuscript is to present a novel application of hybrid effectiveness-implementation designs adaptable to a wide spectrum of pediatric hematology-oncology diseases and contexts. Here, we propose hybrid designs as an option for teams in low-resource settings to evaluate current practice and generate much-needed evidence to inform adoption decisions regarding adapted treatment strategies.
Source: Pediatric Blood & Cancer
DOI: 10.1002/pbc.32005
Institutions: Kamuzu Central Hospital, Texas Children's Hospital, University of North Carolina at Chapel Hill, Baylor College of Medicine, Emma Kinderziekenhuis, Princess Máxima Center, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, University of Washington, The University of Texas MD Anderson Cancer Center
Language: English
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
OpenAlex ID: W4413830863