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Nitric Oxide‐Releasing Catheters with Phenol‐Amine Catalytic Coatings for Improved Anti‐Inflammatory Performance

Year: 2025

Type: article

Abstract: Nitric oxide (NO) is a signaling molecule critical for vasodilation, bacterial inhibition, and inflammation modulation, making it valuable for medical devices, such as catheters. However, existing NO‐releasing catheters face challenges, including maintaining stable NO release over time and complex manufacturing processes. In this study, a robust nanocoating made from tannic acid (TA) and selenocystamine (SeCA) is presented, designed to catalytically generate NO from S ‐nitrosoglutathione in the presence of glutathione. Surface characterization techniques confirmed successful coating formation, with optimal NO generation achieved at a 1:4 TA:SeCA molar ratio. The coated catheters maintained over 96% viability of human coronary artery smooth muscle cells (HCASMCs) after 72 h. It has been demonstrated that the modified catheters significantly increased endogenous NO production in HCASMCs from intracellular S ‐nitrosothiols, highlighting their potential to support vascular function. The coating sustained NO release at 7 × 10 −10 mol cm −2 min −1 for at least 3 days, exceeding the typical release rate of healthy endothelium. Notably, the coating effectively reduced pro‐inflammatory cytokine (TNF‐α and IL‐6) production in RAW 264.7 macrophages upon lipopolysaccharide stimulation, demonstrating anti‐inflammatory effects. This material‐driven approach simplifies NO delivery and offers an effective strategy to enhance catheter efficacy to support vascular function and minimize inflammation.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.202500457