Work

Effect of pH on the Kinetics of Cysteine-to-Cystine Conversion in Thin Films Formed by ESI Microdroplet Deposition

Year: 2025

Type: article

Abstract: The oxidation of cysteine to cystine was investigated in aqueous thin films generated by the deposition of electrospray ionization (ESI) microdroplets. The confined volume of the thin film promotes the reaction, resulting in up to 80% conversion of cysteine to cystine at a thin film temperature of 40 °C. The pH of the solution is a critical parameter, influencing both the yield and the kinetics of the reaction. Strong reaction acceleration factors in thin film with respect to the bulk were measured.

Source: Journal of the American Society for Mass Spectrometry

DOI: 10.1021/jasms.5c00195

Authors: Marta Managò, Chiara Salvitti, Anna Troiani, Alessia Di Noi, Andreina Ricci, Federico Pepi

Institutions: Sapienza University of Rome, University of Campania "Luigi Vanvitelli"

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: NextGenerationEU