Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An EAACI AllergoOncology Scoping Review
Year: 2025
Type: article
Study design: Systematic Review
Abstract: AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and related pathways of human monocytes and macrophages in allergy. An automated search of PubMed and Web of Science databases retrieved 4668 unique articles, which were manually curated based on predefined inclusion and exclusion criteria, yielding 138 eligible studies. From these, we identified 451 molecules associated with monocyte and macrophage responses across allergic disorders. Data analyses revealed a research bias towards blood-derived monocytes, underrepresentation of tissue-resident macrophages, and limited inclusion of miRNAs. Semantic similarity and pathway enrichment analyses highlighted a common molecular signature across major allergic disorders, with consistent enrichment in interleukin signaling and immune activation pathways. To enhance reproducibility and translational utility for researchers and clinicians, we developed ALO•HA, a web application for interactive data exploration. This overview of monocyte and macrophage molecular responses in human allergy underscores the need for integrative, human-focused approaches to better define their roles, and to guide future therapeutic strategies in allergic diseases and at the interface with oncology.
Source: Allergy
DOI: 10.1111/all.16672
Authors: Rodolfo Bianchini, Andrea Escolar‐Peña, Vanda Pick, Aurélie Poli, Rebecca Adams, José Basilio, Luigi Cari, Jitesh Chauhan, Tomás Chivato, Leticia de las Vecillas, María Isabel Delgado‐Dolset, Maria M. Escribese, Melanie Grandits, Heather J. Bax, Isabel Adoración Martín‐Antoniano, Leticia Martín‐Cruz, Hanna Mayerhofer, Alessandro Michelucci, Giuseppe Nocentini, Gabriel Osborn, Carmela Pablo‐Torres, Oscar Palomares, Mariona Pascal, Urszula Radzikowska, Nataliya Rohr‐Udilova, Milena Sokolowska, Christoph Bergmann, Erika Jensen‐Jarolim, Sophia N. Karagiannis, Rocio Rebollido‐Rios, Elena Izquierdo
Institutions: University of Veterinary Medicine Vienna, Universidad San Pablo CEU, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne, Luxembourg Institute of Health, Guy's Hospital, King's College London, Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento, University of Lisbon, Instituto Superior Técnico, Medical University of Vienna, University of Perugia, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Spanish National Cancer Research Centre, Universidad Complutense de Madrid, Harvard University, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, University of Zurich, CK-CARE, Breast Cancer Now
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,300
OpenAlex ID: W4413833412