Work

Characterizing the research participant recruitment funnel for Alzheimer's secondary prevention trials: Results from a survey of U.S. adults

Year: 2025

Type: article

Abstract: Introduction: The steps of participant recruitment are described as a "funnel." In AD secondary prevention trials, the funnel typically yields an unrepresentative study population. Methods: A national survey of U.S. adults aged 65 and over assessed intention to enroll in a hypothetical secondary prevention trial. Among those intending to enroll, intention to ask someone to serve as their study partner was also measured. Results: In the full sample (n=603), intention to enroll - measured on a scale of 1 (very unlikely) to 5 (very likely) - was low (M: 2.37, SD: 1.31). Among those somewhat or very likely to enroll (24%, n=168), mean intention to ask a study partner was 3.45 out of 5 (SD 1.44). There were no significant differences between Black and White respondents. Discussion: Our results suggest underrepresentation of Black older adults in secondary prevention trials is not attributable to lower intention to participate or ask a study partner.

Source: Alzheimer s & Dementia Behavior & Socioeconomics of Aging

DOI: 10.1002/bsa3.70035

Authors: Emily A. Largent, Joshua D. Grill, Jason Karlawish, Amy Bleakley

Institutions: University of Pennsylvania, University of California, Irvine, University of Delaware

Language: English

Topic: Ethics in Clinical Research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: diamond

Funder: National Institute on Aging