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Association between the time for contrast to pass through the myocardium, risk profile and hemodynamic parameters

Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction : The time for contrast to pass through the myocardium (TCPM) is a novel fluoroscopic method proposed for the assessment of coronary microcirculation in patients with non-significant epicardial coronary artery disease. Aim : This study aims to determine the mean TCPM in patients with angina and non-obstructive coronary arteries (ANOCA) and to analyze its relationship with hemodynamic parameters, myocardial mass, and traditional cardiovascular risk factors. Materials and methods : Sixty-two patients with typical angina referred for invasive coronary angiography were enrolled in this prospective observational study. The mean TCPM was measured in all patients. A linear regression analysis was performed to identify independent predictors of TCPM. Results : The mean TCPM was 4.99±1.01 seconds, with values ranging from 3.1 to 7.7 seconds. Regression analysis identified hypertension ( p =0.019) as a positive predictor, while female sex ( p =0.040) and mean arterial pressure ( p =0.009) showed negative associations with TCPM. Traditional cardiovascular risk factors, including dyslipidemia, diabetes, smoking, and age, were not significantly associated with TCPM. Conclusion : A positive association was observed between TCPM and hypertension, while mean arterial pressure and female sex showed an inverse relationship with this parameter. TCPM is a technically simple and reproducible method that could have potential applications in the diagnosis of patients with angina and non-obstructive coronary arteries.
Source: Folia Medica
DOI: 10.3897/folmed.67.e152244
Authors: Rozen K. Grigorov, Stefan Yambolov, Daniel Tsvetkov, Ivaylo Borisov, Svetoslav Georgiev
Language: English
Field: Medicine
Open Access status: diamond
OpenAlex ID: W4413835912
FWCI: 1.066
Cites: 20
Cited by: 2
Related to: 10