Transferosomes: A Highly Effective Vesicular Carrier System for Improved Transdermal Drug Delivery
Year: 2025
Type: article
Abstract: A new vesicular derivative called transferosomes has been created to lessen improper transdermal absorption of both high and low molecular-weight drugs. Surfactants and transferosomes can be used together to enhance drug loading, stability, skin penetration, and controlled drug distribution. They can be used topically or systemically to provide medications, and scaling them up is made simple by their basic processes. Nanotechnology is advancing the development of vesicular drug delivery systems like transferosomes, niosomes, proniosomes, liposomes, ethosomes, and electrosomes.The "osmotic gradient" or transdermal gradient, where an amphiphilic bilayer forms, is the primary method for delivering active chemicals through the skin.The release of medication from transferosomes, which can pass through mucosal layers and aid in the distribution of drugs via transdermal and dermal routes, is governed by the diffusion mechanism.Through the use of a thin film hydration process, transfersomes are created by dissolving surfactant and phosphatelipids in a volatile organic solvent. The finished goods are homogenised by hand extrusions and then exposed to sonication. Transferosomes are useful in the transport of insulin, corticosteroids, proteins, and peptides. They can also be utilised to transport non-steroidal anti-inflammatory drugs, herbal treatments, anaesthetics, and anticancer drugs. KEYWORDS: Transferosomes, Transdermal drug delivery system, Modified Transferosomes, drug carrier.
DOI: 10.55041/ijsrem52269
Author: Bhagya Shree
Institution: Hindu College of Pharmacy
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4413839421