The Impact of Advanced Maternal Age on Embryo Quality and Pregnancy Outcomes in Assisted Reproductive Technologies in Sierra Leone
Year: 2025
Type: article
Study design: Observational Study
Abstract: This study examines the impact of advanced maternal age (AMA) on embryo quality and pregnancy outcomes among women undergoing assisted reproductive technologies (ART) in Sierra Leone. AMA is increasingly recognized as a key factor affecting fertility outcomes, with age-related declines in oocyte quality posing challenges for older women seeking ART. Research at two fertility centers in Freetown involved women aged 35 and older, categorized into age groups (35-39, 40-44, and 45+). Results showed a significant decrease in high-quality embryos and live birth rates with increasing maternal age. Younger cohorts had higher clinical pregnancy rates, while miscarriage rates rose markedly in women over 40, highlighting age-related risks affecting ART success. The study highlights the importance of embryo quality in ART success, with high-quality embryos linked to higher clinical pregnancy and live birth rates. Findings indicate that advanced maternal age reduces the likelihood of successful pregnancy and increases challenges due to higher chromosomal abnormalities. In Sierra Leone, where reproductive healthcare access is limited, AMA adds challenges due to cultural, social, and financial barriers. The study recommends expanding access to preimplantation genetic testing (PGT) and ART education to improve embryo selection and support informed decision-making. The study's implications emphasize the need for policies supporting AMA women, addressing both biological and societal barriers. By promoting affordable ART options and age-sensitive counseling, reproductive health practitioners in Sierra Leone can better assist older women pursuing parenthood. This research enhances the understanding of age-related ART challenges in developing countries, providing insights for improving ART success and access in Sierra Leone and similar contexts.
Source: Science Journal of Public Health
Author: Safuan Sesay
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413842453