Year: 2025
Type: article
Abstract: Mechano-bactericidal (MB) surfaces have been proposed as an emerging strategy for preventing biofilm formation. Unlike antibiotics and metal ions that chemically interfere with cellular processes, MB nanostructures cause physical damage to the bacteria. The antibacterial performance of artificial MB surfaces relies on rational control of surface features, which is difficult to achieve for large surfaces in real-life applications. Herein, a facile and scalable method is reported for fabricating MB surfaces based on metal-organic frameworks (MOFs) using epitaxial MOF-on-MOF hybrids as building blocks with nanopillars of less than 5 nm tip diameter, 200 nm base diameter, and 300 nm length. Two methods of MOF surface assembly, in situ growth and ex situ dropcasting, result in surfaces with nanopillars in different orientations, both presenting MB actions (bactericidal efficiency of 83% for E. coli). Distinct MB mechanisms, including stretching, impaling, and mechanical injury, are discussed with the observed bacterial morphology on the obtained MOF surfaces.
Source: Advanced Science
Authors: Zhejian Cao, Santosh Pandit, Francoise M. Amombo Noa, Jian Zhang, Wengeng Gao, Shadi Rahimi, Lars Öhrström, Ivan Mijakovic
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $6,730
Awards: G1401021190, Graphene-based drug delivery systems for treating MRSA infections (GraMI), G7042228497, G7361212524, Mechanodynamic properties of Metal-Organic Frameworks by topology, building units, and guests investigated by diffraction, scattering, sorption and more, G761937806, Understanding the interaction of graphene-based coating on dental implants and peri-implantitis bacteria
OpenAlex ID: W4413843190