Work

Diagnostic value of inflammatory indexes combined with myocardial enzymes for aneurysmal subarachnoid hemorrhage in patients with intracranial aneurysms

Year: 2025

Type: article

Abstract: Objective The purpose of the study is to evaluate the diagnostic ability of inflammatory indexes alone and in combination with myocardial enzymes in the prediction of aneurysmal subarachnoid hemorrhage (aSAH). Materials and methods This is a 1:1 age- and sex-matched case-control study in Tianjin, China. 226 patients aged >18 years divided into aSAH group and unruptured intracranial aneurysm (UIA) group. Logistic regression models assessed associations between inflammatory indexes/myocardial enzymes and aSAH. Receiver operating characteristic (ROC) curves evaluated their sensitivity/specificity for aSAH. Results Higher neutrophil-to-lymphocyte ratio (NLR) (OR: 1.130, 95% CI: 1.074, 1.188), monocyte-to-lymphocyte ratio (MLR) (OR: 11.144, 95% CI: 3.071, 40.437), platelet-to-lymphocyte ratio (PLR) (OR: 1.006, 95% CI: 1.003, 1.008), systemic immune-inflammatory index (SII) (OR: 1.000, 95% CI: 1.000, 1.001) and systemic inflammation response index (SIRI) (OR: 1.228, 95% CI: 1.112, 1.357), myocardial enzymes lactate dehydrogenase (LDH) (OR: 1.008, 95% CI: 1.003, 1.014), creatine kinase (CK) (OR: 1.002, 95% CI: 1.000, 1.004), and α-hydroxybutyrate dehydrogenase (HBDH) (OR: 1.010, 95% CI: 1.002, 1.018) were all significantly associated with the presence of aSAH. The diagnostic value of inflammatory indexes (NLR-PLR-MLR-SII-SIRI) and myocardial enzymes (LDH-HBDH-CK-CKMB) gave an AUC of 0.771 and 0.662 (all P -value < 0.001), respectively. Combined use of these indexes achieved an AUC of 0.755 ( P -value< 0.001), suggesting potential value as a diagnostic adjunct for aSAH. Conclusions The results suggest that higher inflammatory indexes and myocardial enzymes were associated with the presence of aSAH. The combination of inflammatory indexes and myocardial enzymes may serve as a diagnostic complement for identifying aSAH in patients with IA.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2025.08.023

Authors: Haihong Zhang, Siyuan Dong, Qian Liu, Hongguang Wang

Institutions: Tianjin Huanhu Hospital, Tianjin Medical University, Xinjiang Medical University, Fifth Affiliated Hospital of Xinjiang Medical University

Language: English

Topic: Intracranial Aneurysms: Treatment and Complications

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400