Work

Treatment of Atypical Femoral Fractures After Long-term Administration of Denosumab

Year: 2025

Type: article

Abstract: In recent years, denosumab has been increasingly used to treat osteoporosis.Several articles and studies from the literature have concluded that there is likely an association between chronic denosumab administration and the occurrence of atypical femoral fractures.Synthesizing case reports and systematic reviews, this article provides a comprehensive overview of clinical implications and potential preventive measures.The treatment of choice for these fractures is intramedullary fixation and discontinuation of the anti-osteoporotic drug.This narrative review of the literature examines treatment approaches for these fractures, subsequent therapeutic management of patients, and emphasizes the need for increased clinical awareness and proactive strategies to address the complexity of atypical femoral fractures associated with denosumab.

Source: Journal of Research and Practice on the Musculoskeletal System

DOI: 10.22540/jrpms-09-121

Authors: Lampros Oikonomopoulos, Paraskeuas Asimakis Velitsikakis, Christos Zafeiris, Efstathios Chronopoulos

Institutions: National and Kapodistrian University of Athens, University General Hospital Attikon, KAT General Hospital of Attica

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $107